General approach for tuning PID

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Disclaimer: I've never tuned a PID in a simulator but have tuned PID on motion control systems at work and at home on robots.

Even if you gave me parameters tuned in the worlds best simulator, I would not be willing to just blindly dump them into an untested piece of completed hardware. I would do it the old fashion way and start with P and at a low setting to verify the system is wired correctly and encoders working and circuit breakers aren't popping. Raise them slowly and get a decent response.

Once I was confident the system could be stable and at least mostly responsive, then I'd drop in the parameters from the worlds best simulator.

In a manufacturing setting you can expect that for motion systems there are different sets of parameters that are used depending on the state of assembly and the system function is checked as the system gets built up. You're gonna make sure your lens positioning system is functioning properly before you glue on a $8,000 piece of glass, but it won't be using the same config file when tested without the optic. So even in the real world on well understood systems, it would be considered normal to not just stick in the final PID parameters at the end of assembly if there was risk to it.