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The distortion coefficients do not change if you apply a binning to your image (e.g. to go to a quarter of your resolution). The camera matrix of course changes as it's the conversion from meters to pixels and your right most pixel suddenly is now in column 320 instead of 640. ROS already provides some nice functions that are implemented in image_geometry::PinholeCameraModel. In your case, initialize the class with your 640x480 calibration (with binning_x and binning_y set to 2 to get to your QVGA resolution).