How to run a ros publisher without a while loop?

edit

I am writing tkinter python program for turning on and off the publisher. I need to turn on and off the publisher using a button. If am writing using while loop, the entire gui freezes, I am unable to operate anything. Please give me some suggestions.

dummy = Button(master, text="dummy", relief='groove', command=self.pub_values)
def pub_values(self):
    self.pub = rospy.Publisher('/gateway', Int32MultiArray, queue_size=10)
    rospy.init_node('talker_int', anonymous=True)
    rate = rospy.Rate(1)  # 10hz
    self.var = Int32MultiArray()
    self.var.data = []
    ls = self.extract_values()
    self.var.data = ls
    self.on = True
    while self.on == True:
        rospy.loginfo(self.var)
        self.pub.publish(self.var)
        rate.sleep()

UPDATE: New code after feedback

import rospy, numpy, threading, time
from std_msgs.msg import Int32MultiArray


if __name__ == '__main__':
    x = Simulat()
    try:
        x.t.start()
    except rospy.ROSInterruptException:
        pass

I need to stop or cancel and restart the above program from console. @PeteBlackerThe3rd

Update 2:

Final working code after suggestions

import rospy, numpy, threading, time 
from std_msgs.msg import Int32MultiArray


class Simulat:
    def __init__(self):
        rospy.init_node('talker_int', anonymous=True)        
        self.pub = rospy.Publisher('/gateway', Int32MultiArray, queue_size=10)
        self.rate = rospy.Rate(0.5)  # 10hz
        self.var = Int32MultiArray()
        self.var.data = []
        self.t = threading.Timer(2.0, self.talker_int)
        self.on = True

    def talker_int(self):
        rate = rospy.Rate(1) # 10hz
        var = Int32MultiArray()
        var.data = []
        ls = range(6000, 6041)
        #while not rospy.is_shutdown():
        while self.on == True:
            k = [x+1 for x in ls]
            var.data = k   #% rospy.get_time()
            rospy.loginfo(var)
            self.pub.publish(var)
            rate.sleep()
            ls = k

if __name__ == '__main__':
    x = Simulat()
    try:
        t = rospy.Timer(rospy.Duration(2), x.talker_int)
    except rospy.ROSInterruptException:
       pass