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I've certainly done it before. I had an arm running Hydro, desktop with Indigo, and a laptop with Kinetic. Of course, no one can really say that you won't encounter issues. I had some such as some problems with messages but I don't remember if that was an issue with a package or the different distributions.

I didn't have to do anything more than install the distributions and set the proper environment variables for the master and IP addresses.

I'd imagine that the closer the versions are to each other the better results that you will have. However, that's only a guess.