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CMake doesn't normally look for boost in /opt, so I suspect the third-party software that you've installed has set the CMAKE_PREFIX_PATH or BOOST_ROOT environment variables to point to its version of boost.

CMake only searches for dependencies during configuration time when the build mode, build flags or CMakeLists files change, so it may be that you're only seeing this now because you're changing the build flags, and haven't made other CMakeLists changes in while. I suspect if you clean your workspace and try another devel build, you'll see the same boost issues.