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You can definitely use ROS. Consider how you plan on communicating with the plane. what device will be on the plane to control the motors?

One of the beautiful things about ros is how well it works with other projects. You could integrate ardupilot with ros.

If you don't want to use a flight controller, you could also start with making a teleop plane in ros. Try the rosserial_arduino/Tutorials as a "warmup". You can look at hector_quadrotor.

Good luck, and I look forward to seeing your developments.