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This question is a bit old, but there are some resources online about doing that kind of things. In general, when in doubt, I would recommend looking at how debian does it.

The following page is about building a debian package for a python module that has a setup.py

http://ghantoos.org/2008/10/19/creating-a-deb-package-from-a-python-setuppy/

I don't know about packaging tools for other distributions, but as far as debian-based systems go, debuild makes producing packages of pretty much anything quite easy.